Second Australian National Blood Pressure Study

Funding

Commercial sector/Industry,Merck Sharp Dohme

Scientific enquiries

Prof Christopher Reid

Brief Summary

To determine in hypertensive subjects of 65-84 years of age whether there is any difference in total cardiovascualr events (fatal and non-fatal) over a five year treatment period between antihypertensive treatment with ACE inhibitor-based regimen and treatment with a diuretic-based regimen.

Key Inclusion Criteria

- Are 65-84 years of age - Confirmed hypertension, either untreated or previously treated, with average untreated sitting blood pressure on the 2nd and 3rd screening visits of the study greater than or equal to 160 mmHg or greater than or equal to90 mmHg diastolic (if systolic BP is greater than or equal to 140 mmHg) - Have no history of recent cardiovascular morbidity (see under exclusion criteria), serious intercurrent illness or a absolute contraindication to an ACE inhibitor or diuretic - Ar .... - Are 65-84 years of age - Confirmed hypertension, either untreated or previously treated, with average untreated sitting blood pressure on the 2nd and 3rd screening visits of the study greater than or equal to 160 mmHg or greater than or equal to90 mmHg diastolic (if systolic BP is greater than or equal to 140 mmHg) - Have no history of recent cardiovascular morbidity (see under exclusion criteria), serious intercurrent illness or a absolute contraindication to an ACE inhibitor or diuretic - Are capable of and willing to give informed consent - Are ambulant and able to attend their general practitioner's practise throughout the study
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Key Exclusion Criteria

- Prescence of any previous nonfatal cardiovascular event which defines an end-point for the study in the past 6 months. Refers to any existing condition (eg cancer) which the GP feels is likely to cause death with 5 years. - Accelerated or malignant hypertension - Dementia - Plasma creatinine concentration > 0.2mmol/l. The measurement should have been within the past 12 months or, if this is not available, will be undertaken at the initial screening visit - Any life threatening illness consider .... - Prescence of any previous nonfatal cardiovascular event which defines an end-point for the study in the past 6 months. Refers to any existing condition (eg cancer) which the GP feels is likely to cause death with 5 years. - Accelerated or malignant hypertension - Dementia - Plasma creatinine concentration > 0.2mmol/l. The measurement should have been within the past 12 months or, if this is not available, will be undertaken at the initial screening visit - Any life threatening illness considered to be likely to cause death within the study's observation period (5 years) - Presence of any absolute contraindication to or specific indication for an ACE inhibitor or a diuretic - Consideration by the subject's general practitioner that the subject is unsuitable for the study
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