Data

X-ray Diffraction Images of Pseudomonas aeruginosa DsbA

The University of Queensland
Begoña Heras (Aggregated by) Honorary Professor Jenny Martin (Aggregated by) Jennifer Louise Martin (Aggregated by) Martin Scanlon (Aggregated by)
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ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2FANDS&rft_id=http://dimer.uq.edu.au/projects/padsba/experiments/selmet/datasets/march2008.html&rft.title=X-ray Diffraction Images of Pseudomonas aeruginosa DsbA&rft.identifier=http://dimer.uq.edu.au/projects/padsba/experiments/selmet/datasets/march2008.html&rft.publisher=The University of Queensland&rft.description=This dataset contains diffraction images of Pseudomonas aeruginosa DsbA. A promising new approach to combat antibiotic resistance is by targeting bacterial virulence, rather than bacterial viability. Here we describe the three-dimensional structure of this DsbA target from P. aeruginosa, used to establish for the first time that a member of this enzyme family is capable of binding small molecules. This structural characterization of PaDsbA provides the basis for future studies aimed at designing a new class of antivirulence compounds to combat antibiotic-resistant P. aeruginosa infection.&rft.creator=Begoña Heras&rft.creator=Begoña Heras&rft.creator=Honorary Professor Jenny Martin&rft.creator=Jennifer Louise Martin&rft.creator=Martin Scanlon&rft.creator=Martin Scanlon&rft.creator=Pooja Sharma&rft.creator=Pooja Sharma&rft.creator=Professor Jennifer Louise Martin&rft.creator=Russell Jarrott&rft.creator=Russell Jarrott&rft.creator=Stephen Shouldice&rft.creator=Stephen Shouldice&rft.date=2013&rft.relation=http://www.pdb.org/pdb/explore/explore.do?structureId=3H93&rft.relation=http://www.ncbi.nlm.nih.gov/pubmed/19788398&rft_rights=Diffraction Image Experiment Repository http://creativecommons.org/licenses/by/3.0/rdf&rft_rights=This data is jointly owned by the University of Queensland and current and/or former students of the University of Queensland&rft_subject=Crystallography&rft_subject=X-Ray Diffraction&rft_subject=Structural Biology (incl. Macromolecular Modelling)&rft_subject=BIOLOGICAL SCIENCES&rft_subject=BIOCHEMISTRY AND CELL BIOLOGY&rft_subject=Expanding Knowledge in the Chemical Sciences&rft_subject=EXPANDING KNOWLEDGE&rft_subject=EXPANDING KNOWLEDGE&rft_subject=Expanding Knowledge in the Medical and Health Sciences&rft_subject=Expanding Knowledge in the Biological Sciences&rft.type=dataset&rft.language=English Access the data
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This data is jointly owned by the University of Queensland and current and/or former students of the University of Queensland

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This dataset contains diffraction images of Pseudomonas aeruginosa DsbA. A promising new approach to combat antibiotic resistance is by targeting bacterial virulence, rather than bacterial viability. Here we describe the three-dimensional structure of this DsbA target from P. aeruginosa, used to establish for the first time that a member of this enzyme family is capable of binding small molecules. This structural characterization of PaDsbA provides the basis for future studies aimed at designing a new class of antivirulence compounds to combat antibiotic-resistant P. aeruginosa infection.

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Biochemistry and Cell Biology | Biological Sciences | Crystallography | Expanding Knowledge | Expanding Knowledge | Expanding Knowledge in the Biological Sciences | Expanding Knowledge in the Chemical Sciences | Expanding Knowledge in the Medical and Health Sciences | Structural Biology (Incl. Macromolecular Modelling) | X-Ray Diffraction |

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