Structural and Functional Studies on RNA Nuclear Retention mediated by Paraspeckles: a Novel Gene Regulation [ 2008 - 2013 ]

Research Grant

Researchers: Dr Mihwa Lee (Principal investigator)

Brief description Dynamic interactions between proteins and nucleic acids are essential process in gene regulation, where aberrant regulation leads to various diseases including cancers. The project aims to examine the interactions between paraspeckle proteins and nucleic acid molecules via determination of the structures of protein-nucleic acid complexes at the atomic level. The results will provide a better understanding of a recently discovered gene regulation mechanism and a basis for new gene therapy.

Funding Amount $AUD 290,978.75

Funding Scheme Early Career Fellowships

Notes Peter Doherty Biomedical ECF