Data

Diversity of epithelial-mesenchymal phenotypes in circulating tumour cells from prostate cancer patient-derived xenograft models

Queensland University of Technology
Hassan, Sara ; Blick, Tony ; Thompson, Erik ; Williams, Elizabeth
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ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2FANDS&rft_id=http://researchdatafinder.qut.edu.au/individual/n29264&rft.title=Diversity of epithelial-mesenchymal phenotypes in circulating tumour cells from prostate cancer patient-derived xenograft models&rft.identifier=http://researchdatafinder.qut.edu.au/individual/n29264&rft.publisher=Queensland University of Technology&rft.description=Metastasis is the leading cause of cancer-related deaths worldwide. Epithelial-mesenchymal plasticity (EMP) status of primary tumours has relevance to metastatic potential and therapy resistance. Circulating tumour cells (CTCs) provide a window into the metastatic process, and molecular characterisation of CTCs in comparison to their primary tumours could lead to a better understanding of the mechanisms involved in the metastatic cascade. In this study, paired blood and tumour samples were collected from 4 prostate cancer patient-derived xenograft (PDX) models (BM18, LuCaP70, LuCaP96, LuCaP105) and assessed using an EMP-focused, 42 gene human-specific, nested quantitative RT-PCR assay. CTC burden varied amongst the various xenograft models with LuCaP96 having the highest number of CTCs per mouse (mean: 704; median: 31) followed by BM18 (mean: 101; median: 21), LuCaP70 (mean: 73; median: 16) and LuCaP105 (mean: 57; median: 6). &rft.creator=Hassan, Sara &rft.creator=Blick, Tony &rft.creator=Thompson, Erik &rft.creator=Williams, Elizabeth &rft.date=2021&rft.edition=1&rft.relation=https://eprints.qut.edu.au/209628/&rft.coverage=153.028076,-27.467712&rft_rights=© Queensland University of Technology, 2021.&rft_rights=Creative Commons Attribution 3.0 http://creativecommons.org/licenses/by/4.0/&rft_subject=Prostate cancer&rft_subject=Metastasis&rft_subject=Epithelial mesenchymal plasticity&rft_subject=Patient derived xenograft models&rft_subject=Prostate specific antigen&rft_subject=Circulating tumour cell clusters&rft_subject=Hybrid cells&rft.type=dataset&rft.language=English Access the data
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Creative Commons Attribution 3.0
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© Queensland University of Technology, 2021.

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Contact Information

Postal Address:
Sara Hassan

sara.hassan@hdr.qut.edu.au

Full description

Metastasis is the leading cause of cancer-related deaths worldwide. Epithelial-mesenchymal plasticity (EMP) status of primary tumours has relevance to metastatic potential and therapy resistance. Circulating tumour cells (CTCs) provide a window into the metastatic process, and molecular characterisation of CTCs in comparison to their primary tumours could lead to a better understanding of the mechanisms involved in the metastatic cascade.

In this study, paired blood and tumour samples were collected from 4 prostate cancer patient-derived xenograft (PDX) models (BM18, LuCaP70, LuCaP96, LuCaP105) and assessed using an EMP-focused, 42 gene human-specific, nested quantitative RT-PCR assay. CTC burden varied amongst the various xenograft models with LuCaP96 having the highest number of CTCs per mouse (mean: 704; median: 31) followed by BM18 (mean: 101; median: 21), LuCaP70 (mean: 73; median: 16) and LuCaP105 (mean: 57; median: 6).

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Related Publications

  • Associated with Hassan, Sara, Blick, Tony, Thompson, Rik, & Williams, Elizabeth (2021) Dysregulated epithelial-mesenchymal plasticity in circulating tumour cells from prostate cancer patient-derived xenograft models. Cancers.
    uri : eprints.qut.edu.au/209628/

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153.02808,-27.46771

153.028076,-27.467712

Subjects
Circulating tumour cell clusters | Epithelial mesenchymal plasticity | Hybrid cells | Metastasis | Patient derived xenograft models | Prostate cancer | Prostate specific antigen |

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