{"status":"OK","code":"200","message":{"message_version":"v1.0","api_version":"v2.0","format":"application\/json"},"data":{"numFound":11,"offset":0,"limit":30,"records":[{"id":"74611","key":"http:\/\/purl.org\/au-research\/grants\/arc\/DP0774320","type":"grant","title":"Phospholipids and kinases as regulators of epithelial sodium channels","description":"Phospholipids and kinases as regulators of epithelial sodium channels. The intracellular signalling pathways that will be identified in this project will facilitate the development of novel therapies for the many conditions in which the activity of epithelial sodium channels is abnormal. These include influenza, otitis media, high blood pressure and cystic fibrosis. It will also provide training for post-doctoral fellows and research students in a number of the key techniques in modern cellular physiology.","researchers":["Prof David Cook"],"institutions":null,"status":"CLOSED","fundingAmount":445548,"fundingScheme":"Discovery Projects","startDate":2007,"endDate":2010,"dateTimeModified":"2024-02-06T16:22:11Z","dateTimeCreated":"2013-05-15T13:36:01Z","funder":["ARC Linkage Grant LP1701000985","Australian Research Council"],"managingInstitution":["The University of Sydney","The University of Sydney","University of Sydney"],"principalInvestigator":["Prof David Cook"],"purl":"https:\/\/purl.org\/au-research\/grants\/arc\/DP0774320","identifiers":["https:\/\/purl.org\/au-research\/grants\/arc\/DP0774320","DP0774320"],"subjects":["PHYSIOLOGY","BIOLOGICAL SCIENCES","270602","670403","730115","780105"],"links":[{"rel":"self","href":"http:\/\/researchdata.edu.au\/api\/v2.0\/registry\/activities\/grants\/74611"}]},{"id":"100915","key":"http:\/\/purl.org\/au-research\/grants\/nhmrc\/990351","type":"grant","title":"Intracellular Mechanisms controlling Sodium Channels in Salivary Duct Cells","researchers":["Prof David Cook"],"description":null,"institutions":null,"status":"CLOSED","fundingAmount":394485.44,"fundingScheme":"NHMRC Project Grants","startDate":1999,"endDate":2001,"dateTimeModified":"2017-07-11T08:41:03Z","dateTimeCreated":"2013-05-15T16:57:28Z","funder":["National Health and Medical Research Council"],"managingInstitution":null,"principalInvestigator":["Prof David Cook"],"purl":"https:\/\/purl.org\/au-research\/grants\/nhmrc\/990351","identifiers":["990351","https:\/\/purl.org\/au-research\/grants\/nhmrc\/990351"],"subjects":["MEDICAL AND HEALTH SCIENCES","CHANNEL CONTROL","PATCH-CLAMP","EPITHELIUM","EPITHELIAL SODIUM CH","G-PROTEINS"],"links":[{"rel":"self","href":"http:\/\/researchdata.edu.au\/api\/v2.0\/registry\/activities\/grants\/100915"}]},{"id":"94841","key":"http:\/\/purl.org\/au-research\/grants\/nhmrc\/211138","type":"grant","title":"Regulation of the activity and the surface expression of sodium channels","description":"The regulation of transport of salt into and out of the body is essential for the maintenance of blood pressure, and for the maintenance of the correct amount of fluid in the respiratory passages and gut. A critical component of the mechanism by which the body transports salt are sodium channels. Overactivity of these channels leads to increased blood pressure and clogging of the gut and the bronchi due to thick and sticky secretions. Reduced activity leads to abnormally low blood pressure, as well as to accumulation of fluid in the lungs such as occurs in influenza and in altitude sickness. The present project will examine the mechanisms by which sodium channels are regulated. It will particularly focus on the mechanisms by which sodium channels are switched off when the salt content of cells is too high.","researchers":["Prof David Cook","Prof John Young"],"institutions":null,"status":"CLOSED","fundingAmount":466980,"fundingScheme":"NHMRC Project Grants","startDate":2002,"endDate":2004,"dateTimeModified":"2017-07-11T08:28:56Z","dateTimeCreated":"2013-05-15T15:56:21Z","funder":["National Health and Medical Research Council"],"managingInstitution":null,"principalInvestigator":["Prof David Cook"],"purl":"https:\/\/purl.org\/au-research\/grants\/nhmrc\/211138","identifiers":["211138","https:\/\/purl.org\/au-research\/grants\/nhmrc\/211138"],"subjects":["Medical biotechnology diagnostics (incl. biosensors)","Medical biotechnology","BIOMEDICAL AND CLINICAL SCIENCES","epithelial sodium channels","epithelial transport","patch-clamp","fluid and electrolyte balance","hypertension","renal disease"],"links":[{"rel":"self","href":"http:\/\/researchdata.edu.au\/api\/v2.0\/registry\/activities\/grants\/94841"}]},{"id":"77737","key":"http:\/\/purl.org\/au-research\/grants\/nhmrc\/508086","type":"grant","title":"Physiological function of Nedd4-2 in regulating the epithelial sodium channel","description":"The epithelial sodium channel (ENaC) controls sodium balance, blood volume and blood pressure. Abnormal regulation of ENaC is associated with conditions such as hypertension and pulmonary oedema. Delineating the regulation of ENaC is vital in understanding disease mechanisms and in defining targets for novel therapeutics for the treatment of disorders that arise due to sodium imbalance. This grant will enable us to understand how ENaC is regulated by a novel protein known as Nedd4-2.","institutions":["University of Adelaide"],"researchers":["Prof David Cook","Prof Sharad Kumar"],"status":"CLOSED","fundingAmount":805797.4,"fundingScheme":"NHMRC Project Grants","startDate":2008,"endDate":2010,"dateTimeModified":"2017-07-18T08:20:38Z","dateTimeCreated":"2013-05-15T13:43:01Z","funder":["National Health and Medical Research Council"],"managingInstitution":["University of Adelaide"],"principalInvestigator":["Prof Sharad Kumar"],"purl":"https:\/\/purl.org\/au-research\/grants\/nhmrc\/508086","identifiers":["508086","https:\/\/purl.org\/au-research\/grants\/nhmrc\/508086"],"subjects":["270102","epithelial transport","knockout mice","sodium channel","ubiquitin","ubiquitin-mediated proteolysis","biochemistry and molecular biology","cardiovascular disease and hypertension","ion channel dysfunction","lung function","renel diseases"],"links":[{"rel":"self","href":"http:\/\/researchdata.edu.au\/api\/v2.0\/registry\/activities\/grants\/77737"}]},{"id":"99267","key":"http:\/\/purl.org\/au-research\/grants\/nhmrc\/153938","type":"grant","title":"Interactions between systems that control sodium channels in renal epithelia","description":"The transport of sodium ions by the kidney, gut and lungs not only regulates blood pressure, it also regulates the amount of fluid in the gut and in the lungs. One of the most important proteins that underlie the transport of sodium in these tissues is the so-called epithelial sodium channel. The activity of these epithelial sodium channels is regulated by a wide variety of systems. Some of these regulatory systems act in response to changes in the body's requirements for sodium transport. Others act in response to changes in capacity of cells in which the sodium channels are found to continue transporting sodium. In this project we will study the mechanisms that regulate the activity of the epithelial sodium channels, and in particular, how these mechanisms interact so as to maintain a level of sodium channel activity that is appropriate to both the needs of the organism and to the needs of the sodium transporting cells. The outcomes of this project will be improved understanding of the function of the kidney, gut and lungs in both health and disease. It may also lead to novel drug targets for treatment of major diseases in which the activity of sodium channels is abnormal. These disease include hypertension, cystic fibrosis, pulmonary oedema and influenza.","researchers":["Prof David Cook","Prof John Young"],"institutions":null,"status":"CLOSED","fundingAmount":227036.72,"fundingScheme":"NHMRC Project Grants","startDate":2001,"endDate":2003,"dateTimeModified":"2017-07-11T08:37:27Z","dateTimeCreated":"2013-05-15T16:56:05Z","funder":["National Health and Medical Research Council"],"managingInstitution":null,"principalInvestigator":["Prof David Cook"],"purl":"https:\/\/purl.org\/au-research\/grants\/nhmrc\/153938","identifiers":["153938","https:\/\/purl.org\/au-research\/grants\/nhmrc\/153938"],"subjects":["Medical biotechnology diagnostics (incl. biosensors)","Medical biotechnology","BIOMEDICAL AND CLINICAL SCIENCES","Ussing chamber technique","electrophysiology","epithelial sodium channels","epithelial transport","cystic fibrosis","fluid and electrolyte balance","hypertension","renal disease"],"links":[{"rel":"self","href":"http:\/\/researchdata.edu.au\/api\/v2.0\/registry\/activities\/grants\/99267"}]},{"id":"109218","key":"http:\/\/purl.org\/au-research\/grants\/nhmrc\/1007447","type":"grant","title":"Regulation of epithelial sodium channels by caveolin","description":"Abnormal sodium absorption in the kidney, gut and lung is implicated in hypertension, cystic fibrosis and pulmonary oedema. Epithelial Na+ channels are a key component of the mechanism by which these organs absorb sodium. The project will investigate the mechanisms by which the activity of these channels is controlled and is intended to discover new approaches to treating abnormal sodium absorption.","researchers":["A\/Pr Anuwat Dinudom","Prof David Cook"],"institutions":null,"status":"CLOSED","fundingAmount":408391.56,"fundingScheme":"Project Grants","startDate":2011,"endDate":2014,"dateTimeModified":"2016-01-08T16:55:51Z","dateTimeCreated":"2013-05-15T17:19:47Z","funder":["National Health and Medical Research Council"],"managingInstitution":["The University of Sydney","The University of Sydney","University of Sydney"],"principalInvestigator":["Prof David Cook"],"purl":"https:\/\/purl.org\/au-research\/grants\/nhmrc\/1007447","identifiers":["1007447","https:\/\/purl.org\/au-research\/grants\/nhmrc\/1007447"],"subjects":["Cell Physiology","MEDICAL AND HEALTH SCIENCES","MEDICAL PHYSIOLOGY","epithelial transport","protein kinases","membrane physiology","epithelial function","hypertension","airway oedema","fluid and electrolyte balance"],"links":[{"rel":"self","href":"http:\/\/researchdata.edu.au\/api\/v2.0\/registry\/activities\/grants\/109218"}]},{"id":"100218","key":"http:\/\/purl.org\/au-research\/grants\/nhmrc\/253739","type":"grant","title":"Regulation of the epithelial sodium channel by cytosolic chloride and pro-inflammatory cytokines","description":"The regulation of sodium transport by the epithelial sodium channel is essential for the maintenance of blood pressure and the correct amount of fluid in the respiratory tract and gut. Hyperactivity of the sodium channels leads to increased blood pressure and clogging of the gut and bronchi due to dehydration of the surface fluid. Reductions in the activity of the sodium channels lead to abnormally low blood pressure and the accumulation of fluid in the lungs such as occurs in influenza, high altitude pulmonary oedema and in cardiogenic pulmonary oedema. The present project will examine the mechanisms by which sodium channels are regulated. It will focus on the mechanisms by which cytosolic chloride and inflammatory mediators regulate the activity of the channels.","researchers":["A\/Pr Anuwat Dinudom","Prof David Cook","Prof John Young"],"institutions":null,"status":"CLOSED","fundingAmount":219750,"fundingScheme":"NHMRC Project Grants","startDate":2003,"endDate":2005,"dateTimeModified":"2017-07-11T08:39:58Z","dateTimeCreated":"2013-05-15T16:56:49Z","funder":["National Health and Medical Research Council"],"managingInstitution":null,"principalInvestigator":["A\/Pr Anuwat Dinudom"],"purl":"https:\/\/purl.org\/au-research\/grants\/nhmrc\/253739","identifiers":["253739","https:\/\/purl.org\/au-research\/grants\/nhmrc\/253739"],"subjects":["Medical biotechnology diagnostics (incl. biosensors)","Medical biotechnology","BIOMEDICAL AND CLINICAL SCIENCES","epithelial sodium channel","epithelial transport","patch-clamp","cystic fibrosis","fluid and electrolyte balance","hypertension","pulmonary oedema","renal disease"],"links":[{"rel":"self","href":"http:\/\/researchdata.edu.au\/api\/v2.0\/registry\/activities\/grants\/100218"}]},{"id":"96415","key":"http:\/\/purl.org\/au-research\/grants\/nhmrc\/207708","type":"grant","title":"Regulation of the epithelial sodium channel by the Nedd4-like protein KIAA0439","description":"The epithelial sodium channel (ENaC) is a highly specific ion channel expressed in the apical membrane of some tissues. In the distal nephron of the kidney, ENaC activity is responsible for maintaining sodium balance, blood volume and blood pressure. In the lung ENaC function is required for fluid clearance. Delineating the molecular basis of the regulation of ENaC is vital in understanding disease mechanisms and in defining targets for novel therapeutics for the treatment of disorders that arise due to sodium imbalance. Furthermore, ENaC and the molecules involved in the channel regulatory cascade are potential candidate genes in defining the genetic causes of human hypertension and salt wasting disorders. Previous studies from our laboratories and by other groups have implicated Nedd4, a protein initially cloned by us, as a key player in regulating ENaC. Our recent data suggest that KIAA0439, a close relative of Nedd4, is also involved in ENaC control mechanisms. The work proposed in this application is an extension of our recent findings and will enable us to fully define how KIAA0439 regulates the activity of ENaC.","researchers":["A\/Pr Anuwat Dinudom","Prof David Cook","Prof Sharad Kumar"],"institutions":null,"status":"CLOSED","fundingAmount":452640,"fundingScheme":"NHMRC Project Grants","startDate":2002,"endDate":2004,"dateTimeModified":"2017-07-11T08:31:46Z","dateTimeCreated":"2013-05-15T15:57:29Z","funder":["National Health and Medical Research Council"],"managingInstitution":null,"principalInvestigator":["Prof Sharad Kumar"],"purl":"https:\/\/purl.org\/au-research\/grants\/nhmrc\/207708","identifiers":["207708","https:\/\/purl.org\/au-research\/grants\/nhmrc\/207708"],"subjects":["Medical biotechnology diagnostics (incl. biosensors)","Medical biotechnology","BIOMEDICAL AND CLINICAL SCIENCES","Epithelial transport","Gene knock-out","Molecular biology","Nedd4 family of proteins","Ubiquitin-mediated proteolysis","Cardiovascular disease and hypertension","Disease mechanisms","Genetic disease","Hypertension","Pathophysiology"],"links":[{"rel":"self","href":"http:\/\/researchdata.edu.au\/api\/v2.0\/registry\/activities\/grants\/96415"}]},{"id":"98350","key":"http:\/\/purl.org\/au-research\/grants\/nhmrc\/349320","type":"grant","title":"Mechanisms of Nedd4\/Nedd4-2-mediated regulation of the epithelial sodium channel","description":"The epithelial sodium channel (ENaC) is a highly specific ion channel expressed in the apical membrane of some tissues. In the kidney, ENaC activity is responsible for maintaining sodium balance, blood volume and blood pressure. In the lung ENaC function is required for fluid clearance. Abnormal regulation of ENaC is associated with conditions such as hypertension, cystic fibrosis and pulmonary oedema. Delineating the molecular basis of the regulation of ENaC is vital in understanding disease mechanisms and in defining targets for novel therapeutics for the treatment of disorders that arise due to sodium imbalance. Furthermore, ENaC and the molecules involved in the channel regulatory cascade are potential candidate genes in defining the genetic causes of human hypertension and salt wasting disorders. Previous studies from our laboratories and by other groups have shown that Nedd4 and Nedd4-2 proteins are key players in regulating ENaC activity. Our recent NHMRC supported work has identified another important protein, Grk2, as a regulator of ENaC. The work proposed in this application is an extension of our recent findings and will enable us to fully define how Nedd4-Nedd4-2 and Grk2 regulate the activity of ENaC.","institutions":["University of Adelaide"],"researchers":["A\/Pr Anuwat Dinudom","Prof David Cook","Prof Sharad Kumar"],"status":"CLOSED","fundingAmount":471000,"fundingScheme":"NHMRC Project Grants","startDate":2005,"endDate":2007,"dateTimeModified":"2015-05-06T15:48:45Z","dateTimeCreated":"2013-05-15T16:45:55Z","funder":["National Health and Medical Research Council"],"managingInstitution":["University of Adelaide"],"principalInvestigator":["Prof Sharad Kumar"],"purl":"https:\/\/purl.org\/au-research\/grants\/nhmrc\/349320","identifiers":["349320","https:\/\/purl.org\/au-research\/grants\/nhmrc\/349320"],"subjects":["BIOCHEMISTRY AND CELL BIOLOGY","BIOLOGICAL SCIENCES","Epithelial Transport","Nedd4 family of proteins","Sodium Channels","Ubiquitin-mediated proteolysis","Ubiquitin-protein ligases","Cardiovascular disease and hypertension","Disease mechanisms","Genetic disease","Hypertension","Pathophysiology"],"links":[{"rel":"self","href":"http:\/\/researchdata.edu.au\/api\/v2.0\/registry\/activities\/grants\/98350"}]},{"id":"68184","key":"http:\/\/purl.org\/au-research\/grants\/arc\/LP0774870","type":"grant","title":"New modulators of voltage-gated sodium channel subtypes from Australian Tarantula venoms","description":"New modulators of voltage-gated sodium channel subtypes from Australian Tarantula venoms. The venoms of Australian tarantula spiders provide a unique and untapped source of bioactive molecules. From a large stock of venom, and in collaboration with Australian pharmaceutical company Xenome, we will develop a comprehensive library of venom components suitable for drug screening. Potential national benefits from this work include a huge reduction in the healthcare bill deriving from a new treatment for pain, as well as substantial royalty returns from drugs sales. Discoveries from the program are also likely to lead to an enhancement in Australia's reputation in the neurosciences and to the development of new diagnostic research tools. The major community benefit will be a reduction in the suffering of chronic pain patients.","institutions":["The University of Queensland","University of Queensland"],"researchers":["David John Adams","Dr David Wilson","Professor David Craik"],"status":"CLOSED","fundingAmount":485000,"fundingScheme":"Linkage Projects","startDate":2008,"endDate":2010,"dateTimeModified":"2025-07-16T15:11:47Z","dateTimeCreated":"2013-05-15T12:24:35Z","funder":["ARC Linkage Grant LP1701000985","Australian Research Council"],"managingInstitution":["The University of Queensland","University of Queensland"],"principalInvestigator":["David John Adams","Dr David Wilson","Professor David Craik"],"purl":"https:\/\/purl.org\/au-research\/grants\/arc\/LP0774870","identifiers":["https:\/\/purl.org\/au-research\/grants\/arc\/LP0774870","LP0774870"],"subjects":["BIOCHEMISTRY AND CELL BIOLOGY","BIOLOGICAL SCIENCES","250302","270104","Medical biochemistry - carbohydrates","Medical biochemistry and metabolomics","BIOMEDICAL AND CLINICAL SCIENCES","670403","730104","780105"],"links":[{"rel":"self","href":"http:\/\/researchdata.edu.au\/api\/v2.0\/registry\/activities\/grants\/68184"}]},{"id":"81933","key":"http:\/\/purl.org\/au-research\/grants\/nhmrc\/210307","type":"grant","title":"Engineering subtype selective inhibitors of voltage-sensitive sodium channels","description":"During efforts to find new inhibitors of voltage sensitive sodium channels (VSSCs), we have discovered two new families of mu-conotoxins from Australian Conus tulipa and C. striatus that inhibit neuronal and muscle forms of the tetrodotoxin-sensitive (TTX-S) sodium channel. From these and related analogues we have identified a number of selective and highly potent inhibitors of VSSCs, opening the possibility of producing the first subtype selective TTX-S inhibitors useful in diseases such as epilepsy and stroke. These analogues also showed high selectivity for TTX-S sodium channels over a TTX-resistant (TTX-R) subtype hPN3, a key channel involved in the transmission of neuropathic pain that we recently cloned from human dorsal root ganglia. Given that TTX-S and TTX-R sodium channels have the same overall structure but differ at a relatively small number of key positions likely to affect mu-conotoxin binding, we believe it is possible to reverse engineer mu-conotoxin pharmacology in favour of the TTX-R form. This project will engineer subtype specific inhibitors of sodium channels in nerves through an understanding of how and wheremu-conotoxin bind to the sodium channel. Our long-term goal is to produce sodium channel drug candidates using m-conotoxins as templates for the development of subtype selective inhibitors of TTX-S and TTX-R sodium channels. The results of this study are designed to maximise the potential of this class of peptides as leads to the development of a new classes of therapeutics for pain, epilepsy and stroke.","researchers":["Prof David Adams","Prof Paul Alewood","Prof Richard Lewis"],"institutions":null,"status":"CLOSED","fundingAmount":406980,"fundingScheme":"NHMRC Project Grants","startDate":2002,"endDate":2004,"dateTimeModified":"2017-07-11T08:25:30Z","dateTimeCreated":"2013-05-15T14:47:19Z","funder":["National Health and Medical Research Council"],"managingInstitution":null,"principalInvestigator":["Prof Richard Lewis"],"purl":"https:\/\/purl.org\/au-research\/grants\/nhmrc\/210307","identifiers":["210307","https:\/\/purl.org\/au-research\/grants\/nhmrc\/210307"],"subjects":["Oral and maxillofacial surgery","Dentistry","BIOMEDICAL AND CLINICAL SCIENCES","electrophysiology","molecular pharmacology","peptide structure activity relationships","sodium channel therapeutics","epilepsy","neuropathic pain","stroke"],"links":[{"rel":"self","href":"http:\/\/researchdata.edu.au\/api\/v2.0\/registry\/activities\/grants\/81933"}]}],"links":[{"rel":"grant","href":"http:\/\/researchdata.edu.au\/api\/v2.0\/registry\/activities\/grants"},{"rel":"program","href":"http:\/\/researchdata.edu.au\/api\/v2.0\/registry\/activities\/programs"},{"rel":"project","href":"http:\/\/researchdata.edu.au\/api\/v2.0\/registry\/activities\/projects"},{"rel":"award","href":"http:\/\/researchdata.edu.au\/api\/v2.0\/registry\/activities\/awards"},{"rel":"dataset","href":"http:\/\/researchdata.edu.au\/api\/v2.0\/registry\/activities\/datasets"},{"rel":"funder","href":"http:\/\/researchdata.edu.au\/api\/v2.0\/registry\/activities\/funders"}]}}